发给老马备查:, X6 R- q2 ]# d6 \
滴水察海(69304838) 15:23:23
% n; p5 H" v% s4 ^9 M- E- H+ d老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱+ O' d" Z! K. W. a8 Y9 @) g; {
吉非替尼和S-1连用的依据* x; B$ w' z* g- d, T4 N
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
3 U+ S5 M$ c$ l, p9 Y2 {# b是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
3 K ]5 q* u" Q, s. R& T% o8 h这样是不是推理出,耐药后,可以用S-1和培美了?
1 N; {7 A0 f) q- k结论:
: y7 u; Q% _& B$ C# E- ~* r J如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |