发给老马备查:$ a$ k5 q+ z( W6 r& }, ^5 F, K, z% Q
滴水察海(69304838) 15:23:23 s9 O1 ]! a% i
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱% t- \5 }/ E# G# n
吉非替尼和S-1连用的依据 x; j( h/ x& Y; g
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.& i" ~- `: k+ `
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
/ N9 I O) T# I' `- _这样是不是推理出,耐药后,可以用S-1和培美了?/ k. w& G8 }. j9 Y7 C
结论:
4 k. \/ h1 H1 S2 y如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |