发给老马备查: 8 ~" v$ o# g* n& B# O滴水察海(69304838) 15:23:23 , W7 K* d! b$ U老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱/ O# s& Z* n' n X0 y
吉非替尼和S-1连用的依据 $ s- _( E4 r1 k7 R! [Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro. # e* O7 L1 w5 W' p) o7 ? X是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达! P8 R8 F. g* ~7 p( _
这样是不是推理出,耐药后,可以用S-1和培美了?- B' c2 w, J/ p- s M5 ~
结论: 0 l' f* y8 a! }) W如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。