发给老马备查:
0 }. L( {# ?, g4 w! O( L滴水察海(69304838) 15:23:23+ f3 ^8 @) k- M3 L( K
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱7 c' ^( h* r8 K5 {& S
吉非替尼和S-1连用的依据0 x0 z4 \- T) B. I7 h( }" i
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.+ d) |# z- n( r- J+ S6 m
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达1 l0 a, n( G& \1 V6 Z4 [" d2 J
这样是不是推理出,耐药后,可以用S-1和培美了?0 ]. P. n3 a" a
结论:, j6 D3 {2 }2 f4 ]& G X) H/ M
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |