脑部放疗，上午比下午敏感许多！9 A* u6 F6 s7 y( f
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& R( K; @ T# {4 \) f" Y7 Y' yCancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.
2 |' O9 C$ |/ B' ~* b5 EGamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?
- \' n- D% u! v4 }6 P1 j s& MRahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.$ |$ ^' d. z) t. g1 N8 X
SourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.% ]$ B" f& B$ j9 ?5 b8 N3 v0 ?
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Abstract
% l% b9 Z. s# w& ^# k; Z! {6 q' IBACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.
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METHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.+ a- i; Q2 _+ w5 u' J* a
" H% U a0 _! r7 QRESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).
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CONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.( \5 w9 w/ K% r# E4 J% l: k; R
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家人去世，剩9瓶倍瑞搏，付邮赠送
妈妈去世，家里还有9瓶倍瑞搏，保质期到7月19日，付邮费赠送。有需要的病友可以私信。
求助 K药和替雷利珠如何选择
父亲9月刚查出非小细胞低分化癌伴随左肾上腺和第10胸椎转移PDL1高表达(TPS=90%) SMARC
小细胞肺癌4年9个月倍瑞博营养分享
我家2020.9确诊小细胞肺癌，当时头，肝，肾上腺，综合淋巴都转移，我们马上就进行了放
ASCO速递丨不花一分钱，调整给药时间
作者：seacat
先前的一些回顾性研究提示昼夜节律会影响免疫治疗的疗效，而湖南省肿瘤
麻烦推荐上海肿瘤医院做肾脏手术的医
父亲这两天做ct发现有肿物，医院初步判断不太好，可能需要做手术，求各位推荐上海肿瘤
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显身卡
