看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
3 U+ A% h1 v9 ^; j7 ]5 V# m; `( K9 ^5 C, K) n& X
' ]) P2 u! p$ y6 x' F
Currently available feasibility data for possible combination strategies.
3 @ a2 ~8 ?1 V6 W- e% _, b' f————————————————————————————————, w/ V: Y8 R6 y/ Q% A
Combination Feasibility according to preliminary data
) F! C! F( S: v; w. ^——————————————————————————————————* O7 ]" D! u2 O) c/ ^
Bevacizumab + sorafenib Yes, reduced dose
( F6 z' q- P$ C5 R' U$ }Bevacizumab + sunitinib† No
; I; h; G/ b; f; m" p" t2 p8 \Bevacizumab + temsirolimus Yes 8 h- p# S9 [$ J* r& w: x4 l
Bevacizumab + everolimus Yes o* C- [4 X" Z3 R
Sorafenib + sunitinib ?
; Q9 o: m6 i9 G$ C. zSorafenib + temsirolimus Yes, reduced dose
6 Z" Y8 ?: ^0 U/ _& zSorafenib + everolimus Yes, reduced dose / T' a3 n1 b/ h9 K) q6 F" o
Sunitinib + temsirolimus† No
: a& q7 N6 G' u6 TSunitinib + everolimus ?
' i: d) L, b0 t, F, WTemsirolimus + everolimus ? ! c6 @; @+ T3 d5 t
————————————————————
, f0 z _1 M; v4 u% Z: z†Led to US FDA warning.. m( j5 {' }4 @ E7 C
?: As yet unattempted combination.
5 Y4 [- _2 D+ a- } |